The story of One True Love begins with Ellen, a hardworking janitress who falls madly in love with Carlos, a successful businessman who is already married to Leila. Unknown to Ellen, Carlos is not serious about their whirlwind romance and only becomes aware of his true feelings after finding out that she is pregnant.
Ellen tries to end her ties with Carlos after Leila starts attacking her. But Carlos wants to raise their child and tells Ellen that their child would have a better future with him. Ellen agrees with Carlos but unfortunately, Leila vehemently opposes this idea. She resents raising her husband's illegitimate child so she plots a scheme to switch the child with someone else's.
When Ellen gives birth, Leila is present to "help" out but in truth, she uses this opportunity to switch Ellen's son with another newborn baby girl in the hospital. The moment Ellen sees her child, she immediately falls in love with her baby and tries to back out from the deal she made with Carlos. Furious, Carlos gets Ellen arrested for a fabricated crime so he can get full custody of their child. Helpless and powerless, Ellen swears vengeance on Carlos and Leila.
Meanwhile, Carlos showers his daughter Elize with love and attention not knowing that Leila switched Elize with his real child. His orphaned son grows up in the docks of Manila through the kindness shown by the people in the port district. Because of his mestizo and charming looks, he is given the moniker Tisoy. And by some weird twist of fate, Tisoy ends up working in the port owned by his real father Carlos.
Everything seems to be in place and going well for Tisoy and his adoptive grandmother Lola Tilda until one fateful night when he crosses paths with Elize, the rich daughter of Carlos. Tisoy is completely smitten with Elize's beauty and she finds him charming too. Soon, the two become lovers and keep their romance a secret from Elize's disapproving parents.
How long can Tisoy and Elize weather the odds of their forbidden romance? With Carlos and Ellen threatening to tear them apart, can the star-crossed loversfulfill their destiny to once and for all be together even in the next lifetime? What will happen to Leila if her secret is finally revealed? What will be Carlos' reaction if he finds out the truth about the real identity of Tisoy? Will Ellen continue with her scheme to separate Tisoy and Elize if the truth about their identities is exposed?
With director Andoy Ranay at the helm and original concept by Suzette Doctolero, ONE TRUE LOVE will surely touch and inspire audiences.
