'Barangay 143,' dubbed as the first Filipino anime series in the country, follows the story of Bren Park (Migo Adecer), a young and rising Basketball star in Korea who turns his back to everything that is important to him after a major event changes his life forever. The search for answers leads Bren to Manila where he goes to live with his former nanny Tita Baby (Lorna Tolentino), in the gritty neighborhood of Barangay 143.

Also joining in the star-studded, all-Filipino voice cast are Cherie Gil, Edu Manzano, Alice Dixson, Teresa Loyzaga, Jaime Fabregas, Raver Eda, Pen Medina, Benjie Paras, Archie Alemania, Paolo Contis, Ping Medina, Jerald Napoles, Roadfil Macasero, Nar Cabico, Xandra Rocha, Majoy Baron, Gio Alvarez, Kimpoy Feliciano, Gary Lim, and the Kramer family consist of Cheska, Doug, Kendra, and Scarlet.

'Barangay 143' is a co-production of Synergy88 Entertainment Media Inc. (Philippines) together with August Media Holdings (Singapore), and TV Asahi (Japan).